In November of 1587, a report reached London claiming Sir Walter Raleigh's expedition to land English settlers in America had foundered. The colony on Roanoke Island off of the coast of North Carolina-115 men, women, and children-had disappeared without a trace. For four hundred years, the question of what became of the doomed settlers has remained unanswered. Where did they go? What really happened? Why were they on Roanoke Island in the first place, as that was not their destination? Using her consummate skills as an anthropologist and ethnohistorian, Lee Miller casts new light on the previously inexplicable puzzle of Roanoke, unraveling a thrilling web of deceit that can be traced back to the inner circle of Queen Elizabeth's government to finally solve the lasting mystery of the Lost Colony.