LI-COR IRDye 680RD Azide Infrared Dye, 0.5 mg

IRDye 680RD Azide provides the functionality for preferential labeling of molecules that contain either the alkyne or dibenzocyclooctyne (DBCO) group. Reaction of the IRDye 680RD Azide group with the alkyne group is typically accomplished by copper-catalyzed Click Chemistry, whereas the IRDye 680RD Azide group spontaneously reacts with the DBCO group over a wide range of conditions. Within physiologically-relevant temperature and pH ranges, IRDye 680RD Azide is inert toward naturally occurring nucleophiles such as amines and hydroxyls. However, the azide group is unstable toward sulfhydryls (-SH, thiols) and organophosphines such as tris(2-carboxylethyl)phosphine (TCEP).