Deadpool (2012-2015) #28

ORIGINAL SIN TIE-IN! The shocking truth about Deadpool's family comes to light. Nobody knows the full story of Deadpool's origin, or what happened to his family -- even Wade himself. Manipulated at the hands of Butler and the brutal Weapon Plus program, Wade Wilson was transformed into the indestructible killing machine known as Deadpool. But there is more to the story. Now, thanks to the energies of The Watcher's all-seeing eyes, S.H.I.E.L.D. Agents Adsit and Preston have uncovered the terrible secret of Deadpool's family.