DSPE-PEG-COOH, 3.4k (500mg)

DSPE-PEG-COOH is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and a carboxylic acid. It is a useful self-assembling reagent to prepare PEGylated liposome or micelle while also providing a COOH group for conjugation with amine-containing moleules. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the acid group to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide.