ChemTechBio Monobenzone 5mg

Chemical Characteristic Product Name Monobenzone Synonyms Benoquin, MBEH CAS No. 103-16-2 Molecular Weight 200.23 Formula C13H12O2 Biological activities Monobenzone is the most potent skin depigmenting agent. Monobenzone causes progressive depigmentation and is more effective than the monomethyl ether of hydroquinone (4-methoxyphenol). Monobenzone induces vitiligo and acts as a skin sensitizer. Monobenzone is capable of inducing a systemic autoimmune reaction against pigmented cells, in particular melanocytes or melanoma cells. Monobenzone has a specific and inactivating interaction with tyrosinase, the key enzyme in melanin synthesis present in melanosomes of melanocytes. Monobenzone induces oxidative stress in exposed pigmented cells by producing reactive oxygen species (ROS) such as peroxide upon its catalytic conversion.[1] Monobenzone is a powerful inducer of leukoderma. Monobenzone induces melanosome degradation and autophagy. Monobenzone augments the release of tyrosinase- and melanoma antigen recognized by T cells-1 (MART-1)-containing exosomes by pigmented cells. Monobenzone exposure of melanoma cells triggers the release of intracellular-derived antigenic matter. [2] In vivo, monobenzone, when combined with the immunostimulatory adjuvants imiquimod and CpG (termed MIC therapy), induces effective immunity against subcutaneous malignant B16.F10 melanoma. [1]   References [1] van den Boorn JG, et al. Monobenzone-induced depigmentation: from enzymatic blockade to autoimmunity. Pigment Cell Melanoma Res. 2011, 24(4): 673-679. 　　[2] van den Boorn JG, et al. Skin-depigmenting agent monobenzone induces potent T-cell autoimmunity toward pigmented cells by tyrosinase haptenation and melanosome autophagy. J Invest Dermatol. 2011, 131(6): 1240-1251.