BioFreeze is a topical pain reliever, which contains menthol and ilex. ilex is made from the berries of a holly shrub found in South America and is used in a technique called cryotherapy. BioFreeze works in part by sending cold sensations (similar to icing in sports medicine) to pain receptors and thus interfering with the pain sensation. This process is known as cryotherapy. BioFreeze is widely used and distributed by healthcare professionals for relieving pain in sports injuries, arthritis, sore muscles and joints, sprains, backaches, and even some users have said BioFreeze helps with headaches. The application of BioFreeze gel with the roll-on bottle enhances the effectiveness and convenience by allowing the health care professional or patient to apply the product without getting the product on their handsyet still providing the touch and massaging effect to the afflicted area. This item and all alphabrace.com products come with a 100% satisfaction guarantee.